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This observation is in line with the epidemiological studies, linking pathological impulsivity with weight gain and dysmetabolism ( Multiple psychiatric studies over the past decades established that acetylcholine (ACh) and monoamines (MAs) including norepinephrine, dopamine, histamine, and serotonin are involved in a wide range of psychiatric disorders, including those marked by pathological impulsivity ( The development of PTDs with fewer metabolic adverse effects currently represents a major unmet need in psychiatry
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